Friday November 27 2009 | Biotechnology feed | All feeds
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Friday November 27 2009 | Biotechnology feed | All feeds
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Reversing tumor drug resistance A variety of chemotherapies are available to oncologists and these generally reduce the rate of tumor progression. However intrinsic or acquired tumor-mediated drug resistance is a major clinical obstacle that can result in the lack of tumor responsiveness in patients undergoing treatment. Drug resistance is in part due to active efflux transporters such as p-glycoprotein and consequently the development of inhibitors of this protein represents an active area of the pharmaceutical industry. With this challenge in mind, researchers at The Kitasato Institute in Tokyo have synthesized a series of new isoprenoid derivatives. The lead compound, N-5228 bound to p-glycoprotein and potentiated the accumulation of vincristine in drug-resistant cells. This candidate was therapeutically active in its own right demonstrating efficacy in an in vitro assay of human MDR-type resistant carcinomas. N-5228 was also tested in a xenograft model and demonstrated anti-tumor activity in mice bearing MDR-type resistant tumors. This series thus has anti-cancer potential and further development is eagerly awaited.
Adapted from Hayashi et al, Anticancer Drug Des 2001 Aug-Oct;16(4-5):255-60 Interested in collaborating with this group? Contact leaddiscovery@bioportfolio.co.uk LeadDiscovery and BioPortfolio aims to provide reliable, insightful analysis on the biotechnology industry. However, this information is provided "as is" and no representations or warranties either express or implied of completeness, accuracy, or of any other nature are made with respect to this information. This information is neither an offer to sell nor a solicitation to buy the securities of any company. This information contains forward-looking statements, which involve risks and uncertainties which may not be listed. The biotechnology industry is an emerging industry and the securities of the companies mentioned in this report have a very high degree of risk and volatility. For this reason, this information is supplied on the condition that the reader will make his or her own determination as to its suitability for any purpose prior to any use of this information. The employees and officers of LeadDiscovery and BioPortfolio may hold positions in some or all of the stocks discussed in this report. This abstract has been produced by LeadDiscovery Ltd. Founded by life scientists for life scientists we aim to help industry identify cutting edge drug discovery options and academic/biotech institutions maximize the potential of their research. Abstracts strictly reflect the opinion of LeadDiscovery's editorial panel. While all reasonable efforts are made to ensure the accuracy of information provided LeadDiscovery and the publisher BioPortfolio, takes no responsibility for incorrect or misleading information. LeadDiscovery is designed for educational and drug development purposes only and is not intended or designed to offer medical advice or advice of any sort, and must not be used for such purpose. The information provided through LeadDiscovery and BioPortfolio should not be used for diagnosing or treating a health problem or a disease and no reliance should be placed on any information contained in this abstract or elsewhere on LeadDiscovery's and BioPortfolio's website. It is not intended to be a substitute for professional care. If you have or suspect you may have a health problem, you should consult your physician or other health care provider. |
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