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Sat 04 Feb 2012

Vicks® NyQuil® and Vicks DayQuil® Reveal the NFL Player Least Likely to Take a Sick Day on Super Bowl XLVIProcter & Gamble’s (NYSE: PG) Vicks brand, a proud sponsor of the National Football League and Super Bowl XLVI, announced today the results of a nationwide survey about the NF

Accessory molecules for Toll-like receptors and their functionToll-like receptors (TLRs) have a central role in the initiation of innate and adaptive immune responses. Recent studies have shown that various accessory molecules are required for the biosynthesis and/or activation of several TLRs. A detailed knowledge of these accessory molecules is necessary to better understand the function of TLRs in the immune system.

T cell responses: STAT5 reins in the follicular helpersSTAT5 inhibits follicular helper T cell differentiation by targeting BLIMP1.

Back to Stockholm for ‘metabolism, epigenetics and cell death’

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

Phosphorylation of EBP50 negatively regulates β-PIX-dependent Rac1 activity in anoikis

HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells

Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis

Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complexInsights into Chi recognition from the structure of an AddAB-type helicase–nuclease complexHomologous recombination DNA repair requires double-strand break resection by helicase–nuclease enzymes. The crystal structure of bacterial AddAB in complex with DNA substrates shows that it employs an inactive helicase site to recognize ‘Chi’ recombination hotspot sequences that regulate resection.

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine releaseO-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine releaseThe protein kinase TAK1 plays an important role in pro-inflammatory cytokine signalling. Interleukin-1- and osmotic stress-induced O-GlcNAcylation of its regulatory subunit TAB1 is required for full TAK1 activation to induce downstream cytokine production, linking this protein modification to innate immunity signalling.

Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteinsReversible phosphocholination of Rab proteins by Legionella pneumophila effector proteinsIntracellular bacteria often interfere with the host cell vesicular transport system. Legionella protein AnkX inactivates Rab GTPases by phosphocholination, causing their stable membrane attachment and preventing their interaction with GEFs and cellular effectors.

A role for α-adducin (ADD-1) in nematode and human memoryA role for α-adducin (ADD-1) in nematode and human memoryADD-1 regulates short- and long-term memory in C. elegans and is associated with episodic memory in human. ADD-1 stabilizes actin filaments, regulating synaptic plasticity and maintaining synaptic glutamate receptors during learning.

Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexesArabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexesThe transcription factor E2FA stimulates mutually exclusive plant cell-cycle states, mitotic proliferation and differentiation-associated endocycles. In complex with retinoblastoma protein RBR1, E2FA first maintains proliferation by repressing differentiation genes, while later acting indepen...

Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturationCoordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturationIn vitro reconstitution of Okazaki fragment processing shows that DNA polymerase, flap endonuclease and DNA ligase need to simultaneously bind to the same PCNA-sliding clamp molecule during DNA lagging strand replication.

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesisAkt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesisNogueira et al identify a novel, translational component of AKT to regulate Skp2 level. General significance comes from two distinct biological systems, escape from contact inhibition/oncogenic transformation and adipocyte differentiation.

Complementary treatment of siTERT for improving the antitumor effect of TERT-specific I-131 therapy

Reproducibility of endometrial intraepithelial neoplasia diagnosis is good, but influenced by the diagnostic style of pathologists

Semi-quantitative immunohistochemical assay versus oncotype DX® qRT-PCR assay for estrogen and progesterone receptors: an independent quality assurance study

Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections

Loss of ARID1A/BAF250a-expression in endometriosis: a biomarker for risk of carcinogenic transformation?

Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities

Cholangiocyte cilia are abnormal in syndromic and non-syndromic biliary atresia

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing

Meetings and Conferences: Biotechnology Journal 2/2012

From bench to market: Life science patents in Europe

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