Catachem, Inc. Introduces the Plasma Free Hemoglobin (PFH) In-Vitro

Thursday 1st of January 1970 1:00

Catachem, Inc. Introduces the Plasma Free Hemoglobin (PFH) In-Vitro Diagnostic (IVD) Chemistry Reagent Kit.

Bridgeport, Connecticut, USA (December 8, 2003)…. Catachem, Inc. (Catachem, Private) today announced the development of a new Plasma Free Hemoglobin (Haptoglobin Assay, Free Hemoglobin, FPHB, Hgb, PFH) in vitro diagnostic (IVD) chemistry reagent kit for human and veterinary clinical laboratories.

Serum haptoglobin is most commonly used to detect intravascular destruction (hemolysis) of red blood cells, evaluate hemolytic anemia, and intravascular hemolysis. Plasma hemoglobin is increased with intravascular hemolysis, ABO incompatible transfusion, traumatic hemolysis, falciparum malaria, burns, and march hemoglobinuria. Increase may occur in some cases of extravascular hemolysis, delayed transfusion reaction, slight increase in sickle cell anemia, and thalassemia.  Haptoglobin is a protein that is secreted into the blood by the liver that binds free hemoglobin. The concentration of "free" hemoglobin (that is, outside red blood cells) in plasma (the fluid portion of blood) is ordinarily very low. However, free hemoglobin is released when red blood cells hemolyze for any reason. After haptoglobin binds hemoglobin, it is taken up by the liver. The liver recycles the iron, heme, and amino acids contained in the hemoglobin protein. This process destroys haptoglobin as well as hemoglobin. In the presence of active hemolysis, the rate of haptoglobin destruction will outpace the rate at which new haptoglobin is created. Consequently, the concentration of haptoglobin in the blood will decrease.  Greater-than-normal levels may indicate: acute rheumatic disease, biliary obstruction, peptic ulcer, ulcerative colitis or other inflammatory conditions and lower than normal levels may indicate: chronic liver disease, erythroblastosis fetalis, hematoma, hemolytic anemias, hemolytic anemia due to G6PD deficiency, idiopathic autoimmune hemolytic anemia, immune hemolytic anemia, drug-induced immune hemolytic anemia, primary liver disease or transfusion reaction.  Plasma Free Hemoglobin (PFH), Haptoglobin Assay (Hgb) or Free Hemoglobin (FPHB) is determined using the catalytic action of hemoglobin on the oxidation of TMB by hydrogen peroxide and measured by spectrophotometry. Hemoglobin activates the oxidation of 3.3’,5.5’-tetramethylbenzidine by hydrogen peroxide to form a chromogenic product with maximum absorption at 600 nm. The increase of absorbance is directly proportional to the concentration of hemoglobin in the plasma sample.  PFH is a two reagent chemistry available in one size. R1a and R1b are packaged in glass bottles. R2 is packaged ready-to-use in glass bottles. Calibrator and controls are available separately. PFH Reagents: PFH R1a C454-01,  PFH R1b C454-02, PFH R2 C454-03.

Benjamin Twombly, Vice President Sales and Marketing, commented, “We are excited about the development of this new assay.  PFH provides human and veterinary laboratories better services for their transplant patients”.  Luis P. Leon, President, commented, “The development of new assays in response to customer requests is an important part of the services we provide for our customers”.

About Catachem, Inc.

Catachem has a rich 20 year history in clinical chemistry as a manufacturer and distributor of in-vitro chemistry products and services for human, veterinary and environmental laboratories. Catachem chemists helped develop many of the automated diagnostic chemistries widely in use today.  Catachem created the DiscretePak™ and VetSpec™ line of reagents for human and veterinary automated analyzers.  Catachem offers FDA approved (510K) chemistries (liquid and dry) including enzymatic chemistries developed in conjunction with IFCC and CDC.  Catachem has more than 500 applications for all types of analyzers including the Roche™, Hitachi™, Olympus™, AU Series™, RA Series™, Opera™, DAX™, Bayer™, Advia™, Synchron™, Beckman™, Abbott™ and many other analyzers.  Corporate headquarters, research, custom formulation laboratories, and manufacturing are located in Bridgeport, Connecticut.  Catachem supplies leading laboratories and equipment manufacturers from distributors around the world. 

Forward-looking statements in this release are made pursuant to the ``safe harbor'' provision of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such forward-looking statements involve risks and uncertainties including, but not limited to, the results of research and development efforts, the effect of regulation by the United States Food and Drug Administration and other agencies, the impact of competitive products, product development commercialization and technological difficulties, and other risks detailed in the Company's periodic reports filed with the Securities and Exchange Commission.

Keywords: Catachem, Chemistry, Reagents, In-Vitro Diagnostics, IVD, Plasma Free Hemoglobin, Haptoglobin Assay, Free Hemoglobin, FPHB, Hgb, PFH

For more information contact:

Benjamin Twombly
Catachem, Inc.
70 Hawley Avenue
Bridgeport, CT
USA 06606
+1 (203) 335-9277 Office
+1 (203) 335-9977 FAX
bentwombly@aol.com
catachem@aol.com
www.catacheminc.com

Ref: C3010c

Catachem chemistries include: 5'-Nucleotidase (5NT), Adenosine Deaminase (ADA), Alanine Aminotransferase (ALT), Albumin BCG (ALB), a-L-Fucosidase (AFU), Alkaline Phosphatase (ALP), Ammonia (NH), Amylase (AMY), Aspartate Aminotransferase (ALP), β-Hydroxybutyrate (BHBA), Bicarbonate (HC03), Bile Acids (BA), Bilirubin, Direct with Blank (DBILI), Bilirubin, Total with Blank (TBILI), Bilirubin, Total (TBILI), Blood Urea Nitrogen (BUN), Bromide (BR), CO2 [340] (CO2), CO2 [380] (CO2), CO2 [single reagent] (CO2), Ca+++ Arsenazo [650NM] (CA3), Chloride [340 NM] (CL), Cholesterol (CH), Creatine Kinase (CK), Creatinine (CREAT), Fructosamine [millimole method] (FR), Fructosamine, Glycated Serum Protein [enzymatic] (FR), Gamma-Glutamyl Transpeptidase (GGT), Glucose Hexokinase (GLU), Glycated Hemoglobin (HbA1c), High Density Lipoproteins, Dextran Sulfate (HDL), Inorganic Phosphorus (IP), Lactate Dehydrogenase (LD), Lipase (LIP), Lithium [enzymatic] (LI), Magnesium (MG), N-Acetyl-ß-D-glucosaminidase (NAG), Potassium [enzymatic] (K), Plasma Free Hemoglobin (PFH), Pre-albumin (TBPA), Sodium [enzymatic] (NA), Sorbitol Dehydrogenase (SDH), Thiopurine methyltransferase (TPMT), Total Bile Acids (TBA), Total Iron (TI), Total Protein (TP), Triglycerides (TRIG), UIBC and TIBC (UIBC), Uric Acid (UA), Vitamin B6 (V6B), Multipoint Calibrator Catacal, Catatrol Level 1 Catatrol Level 2, Bile Acids Control, Bile Acids Calibrator, BHBA Calibrator, BHBA Control Level 1, BHBA Control Level 2; Bromide Calibrator, BR Control Level 1, BR Control Level 2; Fructosamine Calibrator, FR Control Level 1, FR Control Level 2, SDH Control Level 1, SDH  Control Level 2.  Call +1 (203) 335-9277 or Write Catachem@aol.com.

 
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