Thursday November 26 2009 | Biotechnology feed | All feeds
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Thursday November 26 2009 | Biotechnology feed | All feeds
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Bridgeport,
Connecticut, USA (December 8, 2003)…. Catachem, Inc. (Catachem, Private) today
announced the development of a new Plasma Free Hemoglobin
(Haptoglobin
Assay, Free Hemoglobin, FPHB, Hgb, PFH) in vitro
diagnostic (IVD) chemistry reagent kit for human and veterinary clinical
laboratories. Serum haptoglobin is
most commonly used to detect intravascular destruction (hemolysis) of red blood
cells, evaluate hemolytic anemia, and intravascular hemolysis. Plasma hemoglobin
is increased with intravascular hemolysis, ABO incompatible transfusion,
traumatic hemolysis, falciparum malaria, burns, and march hemoglobinuria.
Increase may occur in some cases of extravascular hemolysis, delayed transfusion
reaction, slight increase in sickle cell anemia, and thalassemia. Haptoglobin
is a protein that is secreted into the blood by the liver that binds free
hemoglobin. The concentration of "free" hemoglobin (that is, outside
red blood cells) in plasma (the fluid portion of blood) is ordinarily very low.
However, free hemoglobin is released when red blood cells hemolyze for any
reason. After haptoglobin binds hemoglobin, it is taken up by the liver. The
liver recycles the iron, heme, and amino acids contained in the hemoglobin
protein. This process destroys haptoglobin as well as hemoglobin. In the
presence of active hemolysis, the rate of haptoglobin destruction will outpace
the rate at which new haptoglobin is created. Consequently, the concentration of
haptoglobin in the blood will decrease. Greater-than-normal
levels may indicate: acute
rheumatic disease, biliary
obstruction, peptic
ulcer, ulcerative
colitis or other inflammatory conditions and lower than normal levels
may indicate: chronic liver
disease, erythroblastosis
fetalis, hematoma, hemolytic
anemias, hemolytic
anemia due to G6PD deficiency,
idiopathic
autoimmune hemolytic anemia, immune
hemolytic anemia, drug-induced immune hemolytic anemia, primary
liver disease or transfusion
reaction. Plasma Free Hemoglobin (PFH), Haptoglobin Assay (Hgb) or Free Hemoglobin
(FPHB) is determined using the catalytic action of hemoglobin on the oxidation
of TMB by hydrogen peroxide and measured by spectrophotometry. Hemoglobin
activates the oxidation of 3.3’,5.5’-tetramethylbenzidine by hydrogen
peroxide to form a chromogenic product with maximum absorption at 600 nm. The
increase of absorbance is directly proportional to the concentration of
hemoglobin in the plasma sample. PFH
is a two reagent chemistry available in one size. R1a and R1b are packaged in
glass bottles. R2 is packaged ready-to-use in glass bottles. Calibrator and
controls are available separately. PFH Reagents: PFH R1a C454-01, PFH R1b C454-02, PFH R2 C454-03. Benjamin
Twombly, Vice President Sales and Marketing, commented, “We are excited about
the development of this new assay. PFH
provides human and veterinary laboratories better services for their transplant
patients”. Luis P. Leon,
President, commented, “The development of new assays in response to customer
requests is an important part of the services we provide for our customers”. About
Catachem, Inc. Catachem
has a rich 20 year history in clinical chemistry as a manufacturer and
distributor of in-vitro chemistry products and services for human, veterinary
and environmental laboratories. Catachem chemists helped develop many of the
automated diagnostic chemistries widely in use today. Catachem created the DiscretePak™
and VetSpec™ line of reagents
for human and veterinary automated analyzers.
Catachem offers FDA approved (510K) chemistries (liquid and dry)
including enzymatic chemistries developed in conjunction with IFCC and CDC.
Catachem has more than 500 applications for all types of analyzers
including the Roche™, Hitachi™, Olympus™,
AU Series™, RA Series™, Opera™,
DAX™, Bayer™, Advia™,
Synchron™, Beckman™, Abbott™
and many other analyzers. Corporate
headquarters, research, custom formulation laboratories, and manufacturing are
located in Bridgeport, Connecticut. Catachem
supplies leading laboratories and equipment manufacturers from distributors
around the world. Forward-looking
statements in this release are made pursuant to the ``safe harbor'' provision of
the Private
Securities Litigation Reform Act of 1995. Investors are cautioned that such
forward-looking statements involve risks and uncertainties including, but not
limited to, the results of research and development efforts, the effect of
regulation by the United States Food and Drug Administration and other agencies,
the impact of competitive products, product development commercialization
and technological difficulties, and other risks detailed in the Company's
periodic reports filed with the Securities and Exchange Commission. Keywords:
Catachem, Chemistry, Reagents, In-Vitro Diagnostics, IVD, Plasma Free Hemoglobin, Haptoglobin
Assay, Free Hemoglobin, FPHB, Hgb, PFH For
more information contact: Benjamin
Twombly Catachem
chemistries include: 5'-Nucleotidase (5NT), Adenosine Deaminase (ADA), Alanine
Aminotransferase (ALT), Albumin BCG (ALB), a-L-Fucosidase (AFU), Alkaline
Phosphatase (ALP), Ammonia (NH), Amylase (AMY), Aspartate Aminotransferase
(ALP), β-Hydroxybutyrate (BHBA), Bicarbonate (HC03), Bile Acids (BA),
Bilirubin, Direct with Blank (DBILI), Bilirubin, Total with Blank (TBILI),
Bilirubin, Total (TBILI), Blood Urea Nitrogen (BUN), Bromide (BR), CO2 [340]
(CO2), CO2 [380] (CO2), CO2 [single reagent] (CO2), Ca+++ Arsenazo [650NM]
(CA3), Chloride [340 NM] (CL), Cholesterol (CH), Creatine Kinase (CK),
Creatinine (CREAT), Fructosamine [millimole method] (FR), Fructosamine, Glycated
Serum Protein [enzymatic] (FR), Gamma-Glutamyl Transpeptidase (GGT), Glucose
Hexokinase (GLU), Glycated Hemoglobin (HbA1c), High Density Lipoproteins,
Dextran Sulfate (HDL), Inorganic Phosphorus (IP), Lactate Dehydrogenase (LD),
Lipase (LIP), Lithium [enzymatic] (LI), Magnesium (MG), N-Acetyl-ß-D-glucosaminidase
(NAG), Potassium [enzymatic] (K), Plasma Free Hemoglobin (PFH), Pre-albumin (TBPA),
Sodium [enzymatic] (NA), Sorbitol Dehydrogenase (SDH), Thiopurine
methyltransferase (TPMT), Total Bile Acids (TBA), Total Iron (TI), Total Protein
(TP), Triglycerides (TRIG), UIBC and TIBC (UIBC), Uric Acid (UA), Vitamin B6
(V6B), Multipoint Calibrator Catacal, Catatrol Level 1 Catatrol Level 2, Bile
Acids Control, Bile Acids Calibrator, BHBA Calibrator, BHBA Control Level 1,
BHBA Control Level 2; Bromide Calibrator, BR Control Level 1, BR Control Level
2; Fructosamine Calibrator, FR Control Level 1, FR Control Level 2, SDH Control
Level 1, SDH Control Level 2. Call
+1 (203) 335-9277 or Write Catachem@aol.com. |
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