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Genomatix Adds Cell-Based Knockins To Its Vector Application ServicesROANOKE,
VA (June 3, 2004).
Genomatix Corporation has announced the addition of Cell-Based Knockins
to its growing list of DNA vector applications.
Cell knockins allow life scientists to compare the effects of adding new
or modified genetic materials into the functional context of a total gene
knockout. The
knockout/knockin modification is accomplished in a two step process involving a
single allele knockout of a targeted gene followed by knockin of new or modified
genetic material at the same locus on the second allele.
The result is a knockin cell line which is homozygous for the gene
knockout. There
are many research opportunities for cell knockin applications, including the
study of mutant forms of the knockout gene.
According
to Genomatix' chief scientist, Thomas Reed, Ph.D., the company's cell knockin
vectors offer researchers a way to avoid premature knockout/knockin studies in
transgenic animal models.
"Our cell-based knockin vectors often represent a better first
step," says Reed.
"It's far less expensive and time-consuming to first culture, select
and study cells, than to raise, crossbreed and study animals."
The company, however, understands that researchers will often need to
complete their studies using knockout/knockin animal models.
To that end, Reed mentioned an important bonus, "Our UltraVector™
technology has been designed for direct reuse of our vectors from cells to
animals. Once
the best vector combination has been determined in comparative cell studies, the
same vectors can be reused, without reassembly, to generate an animal
model."
Genomatix
is a genetic materials manufacturing company that specializes in the modular
production of combinatorial vector sets that are used for comparative transgenic
studies. In
the case of cell-based knockins, modular combinations of knockin vectors are
manufactured for locus-specific recombination into the knockout cell line.
Selected knockin cells can then be compared to determine which vectors
yielded the most definitive or promising results.
Additional information about cell knockins is located on the company's
website at www.genomatix.com/CellKnockIn.cfm. PRESS
CONTACT: Robert
Beech CEO,
Genomatix 540-345-4333 # |
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