Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

15:42 EDT 23rd August 2017 | BioPortfolio

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Showing News Articles 26–50 of 34,000+ from Nature Publishing

Wednesday 23rd August 2017

Direct-acting antiviral agents for HCV infection affecting people who inject drugs

Direct-acting antiviral agents (DAAs) are highly effective treatments for HCV, but are not always accessible to people who inject drugs (PWID). Here, Grebely and colleagues outline the epidemiology of HCV in PWID, discuss current data on DAA outcomes in this population and highlight steps required to broaden access to HCV therapy with the eventual goal of HCV elimination.

Colorectal cancer: Early MRI imaging predicts regorafenib response

Lower gastrointestinal tract: What are normal bowel movement patterns?

Coeliac disease: Blood test for diagnosis more effective than biopsy

Tuesday 22nd August 2017

Pairing of integrins with ECM proteins determines migrasome formation

Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis

Sex-specific transcriptional signatures in human depression

Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

On the basis of new mechanistic studies of a mutant form of the apolipoprotein apoC-III that protects against coronary heart disease, Khetarpal et al. have developed therapeutic apoC-III-targeting monoclonal antibodies that lower circulating apoC-III protein and triglyceride levels in mice.

Targeting cellular senescence prevents age-related bone loss in mice

Genetic or pharmacological depletion of senescent cells or inhibition of their function reduces bone loss in aged mice.

Tamm–Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract

Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent

The MARCH family joins the antigen cross-presentation party

Evolution and cancer medicine — transformative insights

Few clinical trials incorporate studies of evolutionary cancer biology, despite the frequent emergence of acquired resistance to anticancer therapies. This problem motivated the first CRUK Marshall Symposium on Cancer Evolution in May 2017, which provided a forum for evolutionary and ecological theorists, cancer biologists, and clinicians to consider how evolutionary biology might inform improveme...

A further strategy to combat the high price of anticancer drugs

Breast cancer: Brain metastasis detectable in CTCs

Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release

Modifiable risk factors in the first 1000 days for subsequent risk of childhood overweight in an Asian cohort: significance of parental overweight status

Metabolic effects of resistance or high-intensity interval training among glycemic control-nonresponsive children with insulin resistance

Effects of peripheral administration of a Neuromedin U receptor 2-selective agonist on food intake and body weight in obese mice

Birth by cesarean section in relation to adult offspring overweight and biomarkers of cardiometabolic risk

Education as a moderator of genetic risk for higher body mass index: prospective cohort study from childhood to adulthood

Pathways from senescence to melanoma: focus on MITF sumoylation

The long noncoding RNA SNHG1 promotes tumor growth through regulating transcription of both local and distal genes

Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells

S100A7: from mechanism to cancer therapy

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