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02:14 EDT 31st August 2016 | BioPortfolio

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Tuesday 30th August 2016

Two-dimensional gallium nitride realized via graphene encapsulation

A method to synthesize 2D layers of gallium nitride on SiC is reported. Epitaxial graphene preliminarily grown on SiC allows intercalation of gallium atoms on the SiC substrate and stabilizes the 2D gallium nitride islands formed by ammonolysis.

Materials synthesis: Two-dimensional gallium nitride

Graphene is used as a capping sheet to synthesize 2D gallium nitride by means of migration-enhanced encapsulation growth. This technique may allow the stabilization of 2D materials that are not amenable to synthesis by traditional methods.

Amorphous solids: Rayleigh scattering revisited

Scaling of the phonon damping with the wavevector in glasses is found to be different from the traditionally assumed Rayleigh scattering, and related to surprising, long-range correlations in the local elasticity matrix.

p62 improves AD-like pathology by increasing autophagy

Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism

Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology

Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

Vibrio natriegens as a fast-growing host for molecular biology

A suite of tools and resources for Vibrio natriegens introduces the bacterium as a faster-growing alternative to E. coli for molecular biology and biotechnology applications.

MetaMass, a tool for meta-analysis of subcellular proteomics data

A straightforward method and tool, MetaMass, utilizes a list of subcellular markers to analyze and classify subcellular proteomics data from multiple experiments. An accompanying analysis reveals a wide variation in the results of subcellular fractionation protocols.

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

rG4-seq enables the mapping of RNA G-quadruplex structures across entire transcriptomes at nucleotide resolution.

Diffusion pseudotime robustly reconstructs lineage branching

Diffusion pseudotime (DPT) enables robust and scalable inference of cellular trajectories, branching events, metastable states and underlying gene dynamics from snapshot single-cell gene expression data.

Stable long-term chronic brain mapping at the single-neuron level

Flexible mesh electronics facilitate stable long-term recordings of the same single neurons in mouse brains over months, enabling chronic recordings in behaving animals and longitudinal studies to resolve aging-dependent changes in neural activity.

Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1

Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy

Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

T follicular helper cells in space-time

This Review discusses our current understanding of the development and functions of follicular helper T (TFH) cells. The author explains how these cells do not fit with the classical instructional model of helper T cell differentiation and, instead, proposes a model of default TFH cell development with inherent spatiotemporal stochasticity.

Innate lymphoid cells: ILC diversity maintained by microbiota

Single-cell genomic analysis of ILCs from the mouse small intestine identifies high levels of diversity that are maintained by the commensal microbiota.

Inferring expressed genes by whole-genome sequencing of plasma DNA

Michael Speicher and colleagues analyze plasma DNA whole-genome sequencing data from healthy donors and patients with cancer to infer nucleosome positioning on the basis of read depth coverage patterns. They use this approach to accurately predict expression of cancer driver genes from circulating tumor DNA in regions with somatic copy number gains.

Next-generation genotype imputation service and methods

Christian Fuchsberger, Gonçalo Abecasis and colleagues describe a new web-based imputation service that enables rapid imputation of large numbers of samples and allows convenient access to large reference panels of sequenced individuals. Their state space reduction provides a computationally efficient solution for genotype imputation with no loss in imputation accuracy.

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer

Mathieu Lupien and colleagues report an enrichment of somatic mutations at the ESR1 cis-regulatory region in 7% of ESR1-positive breast cancers. They find that the activity of the recurrently mutated ESR1 enhancer is also influenced by breast cancer risk–associated SNPs.

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts

Yanick Crow and colleagues report that biallelic mutations in SNORD118, which encodes the box C/D snoRNA U8, cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts. The mutations affect U8 expression, processing and protein binding and suggest a role for this snoRNA in cerebral vascular homeostasis.

Serious adverse events reported for antiobesity medicines: postmarketing experiences from the EU adverse event reporting system EudraVigilance

Differences in fairness and trust between lean and corpulent men

Sleep and meal-time misalignment alters functional connectivity: a pilot resting-state study

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