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Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

13:23 EDT 27th June 2017 | BioPortfolio

Here are the most relevant search results for "Nature Publishing" found in our extensive news archives from over 250 global news sources.

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Showing News Articles 26–50 of 32,000+ from Nature Publishing

Monday 26th June 2017

Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells

Germinal centers generate high-affinity memory B cells. Qi and colleagues identify a precursor of memory B cells in germinal centers and demonstrate that the cytokine IL-9-derived from follicular helper T cells is important for their development into full-fledged memory cells.

Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors

Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or around the hematopoietic-stem-cell stage, starting as a lineage bias defined by transcriptional programs that correlate with the combinatorial dose of IRF8 and PU.1.

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

Ultrafast-scanning fluorescence correlation spectroscopy has now been used to measure the molecular interactions underlying the phase behaviour of disordered proteins. Sequence-encoded conformational fluctuations of these proteins are shown to give rise to phase-separated droplets of surprisingly low concentrations. These results provide insight into how the structural features of the droplets aff...

Thermally bisignate supramolecular polymerization

An attractive feature of supramolecular polymers is their reversibility — they typically depolymerize upon heating. Now, in the presence of a scavenger molecule, a metalloporphyrin derivative bearing eight amide-containing side chains has been shown to undergo supramolecular polymerization on heating as well as cooling through π-stacking and multivalent hydrogen-bonding interactions.

A new and selective cycle for dehydrogenation of linear and cyclic alkanes under mild conditions using a base metal

The direct conversion of linear alkanes to α-olefins, selectively, and without isomerization is a paradigm in the field of catalysis. We show a detailed pathway for how a base metal can promote such a reaction with several turnovers, in a non-oxidative set of C–H activation reactions, thus preventing olefin isomerization.

Direct, enantioselective α-alkylation of aldehydes using simple olefins

The catalytic asymmetric α-alkylation of aldehydes has historically been a significant challenge within organic synthesis. Now, this elusive transformation has been achieved through the merger of organocatalysis, photoredox catalysis and hydrogen-atom transfer catalysis to enable the coupling of simple olefins and aldehydes.

Glomerular filtration rate: CKD risk factors are associated with increased single-nephron GFR

Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia

An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression

Signaling coupled epigenomic regulation of gene expression

Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling

MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance

β-catenin downregulates Dicer to promote ovarian cancer metastasis

MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease

Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro

C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling

Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ

The novel α-glucan YCP improves the survival rates and symptoms in septic mice by regulating myeloid-derived suppressor cells

Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

A DNA origami platform for quantifying protein copy number in super-resolution

A DNA-origami-based calibration method determines and accounts for labeling stoichiometry and fluorophore photophysics to improve protein counting in quantitative super-resolution imaging.

CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping

CrY2H-seq, a Cre recombinase reporter-mediated yeast two-hybrid method coupled with next-generation sequencing, enables ultra-high-throughput screening of transcription factor interactions in Arabidopsis thaliana.


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