Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

17:21 EDT 24th May 2017 | BioPortfolio

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Showing News Articles 26–50 of 31,000+ from Nature Publishing

Wednesday 24th May 2017

Body mass index and depressive symptoms in adolescents in Taiwan: testing mediation effects of peer victimization and sleep problems

Methods for quantifying adipose tissue insulin resistance in overweight/obese humans

Joint effect of maternal plasma homocysteine and prepregnancy obesity on child blood pressure: a prospective birth cohort study

Is body mass index associated with lowest mortality increasing over time?

Central fat accretion and insulin sensitivity: differential relationships in parous and nulliparous women

Parental optimism about childhood obesity-related disease risks

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

On food supply and obesity, missing the point is easy

5-methylcytosine mediates nuclear export of mRNA

Definitions of traumatic conus medullaris and cauda equina syndrome: a systematic literature review

Estimating the Basal metabolic rate from fat free mass in individuals with motor complete spinal cord injury

A comparative study of two protocols for treadmill walking exercise testing in ambulating subjects with incomplete spinal cord injury

Tuesday 23rd May 2017

A cerebellum-like circuit in the auditory system cancels responses to self-generated sounds

The authors provide evidence that a cerebellum-like structure at the initial stage of mammalian auditory processing (the dorsal cochlear nucleus) functions to cancel out self-generated sounds. A similar function has been established for cerebellum-like structures in electroreceptive fish, suggesting a conserved function for these structures across vertebrates.

Flexible information routing by transient synchrony

Brain function relies on flexible communication between cortical regions. It has been proposed that changing patterns of oscillatory coherence underlie information routing. However, oscillations in vivo are very irregular. This study shows that short-lived and stochastic oscillatory bursts coordinate across areas to selectively modulate interareal communication.

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

The authors monitored neuronal activity in mouse visual cortex during visual-motion stimulation and perturbed retinal direction selectivity. After perturbation, the proportion of posterior-motion-preferring cortical cells decreased, and their response at higher stimulus speeds was reduced. Thus, functionally distinct, retina-dependent and retina-independent computations of visual motion exist in m...

PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

The authors identify programmed cell death ligand-1 (PD-L1), an immunity suppressor produced by cancer cells, as a new pain inhibitor and a neuromodulator. They report that PD-L1 is produced by melanoma and normal neural tissues and that it inhibits acute and chronic pain. Via activation of PD-1, its receptor, PD-L1 decreases the excitability of nociceptive neurons in mouse and human dorsal root g...

Combining drugs and extending treatment — a PFS end point is not sufficient

In studies investigating the combination of two or more anticancer drugs that are already approved for independent use, or 'maintenance' regimens, the use of progression-free survival as the end point for approval is inadequate; sequential treatment with the same agents or existing salvage therapies, respectively, might provide an equivalent survival benefit, with lower toxicity, cost, and treatme...

Scientific advice — is drug repurposing missing a trick?

Scientific Advice meetings are a mechanism to improve communications between drug developers and regulators during the drug-development process. While standard practice for industry, the benefits provided by these meetings are under-utilised by academia. In the context of drug repurposing, can scientific advice, as part of a proposed new R&D tax credits scheme, help to unblock some of the obstacle...

Unravelling the biology of SCLC: implications for therapy

For three decades, the treatment of small-cell lung cancer (SCLC) has remained essentially unchanged, and patient outcomes remain dismal. In the past 5 years, however, advances in our understanding of the disease, at the molecular level, have resulted in the development of new therapeutic strategies, encompassing immunotherapies and novel molecularly targeted agents. Herein, authors review the bre...

Skin cancer: Mutational landscape of melanoma revealed

Haematological cancer: Pembrolizumab is effective in multiple myeloma

Prostate cancer: AR mutations in plasma DNA indicate outcomes

Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome

The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders

No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden

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