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10:50 EDT 2nd September 2015 | BioPortfolio

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Showing News Articles 26–50 of 14,000+ from Nature Publishing

Wednesday 2nd September 2015

Gastrointestinal cancer: CROSS: new standard of care for oesophageal cancer

Development and validation of a computerized algorithm for International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)

Tuesday 1st September 2015

The global burden of IBD: from 2015 to 2025

IBD is a chronic, incurable disease and can be a major burden to health-care resources. Moreover, the epidemiology of IBD is changing worldwide. In this Perspectives, Gilaad Kaplan discusses the current global burden of IBD an...

Caring for children with NAFLD and navigating their care into adulthood

With a growing population of children developing NAFLD, our understanding of the similarities and differences between paediatric, adolescent and adult NAFLD is getting ever more important. In this Review, Mencin, Loomba and La...

Hepatitis: Epigenetic control of HBV by HBx protein—releasing the break?

HBV persists by depositing covalently closed circular DNA (cccDNA) into the nucleus of infected host cells. HBV X protein (HBx) is a crucial determinant for regulating HBV activity, but the molecular details have not been fully understood. A new role...

Helicobacter pylori: Lessons in bacterial attraction

Gut microbiota: Lactobacillus acidophilus opens the door to butyrate

Developmental biology: On the origin of liver regeneration

Dysfunctional HDL and atherosclerotic cardiovascular disease

High-density lipoproteins (HDLs) have various antiatherosclerotic effects; however, inflammation can cause HDL to become dysfunctional, which impairs its protective properties. In this Review, Rosenson and colleagues discuss the mechanisms by which H...

Interventional cardiology: Optimal coronary interventional strategies for in-stent restenosis

The emerging threat of multidrug-resistant Gram-negative bacteria in urology

Urinary tract infections (UTIs) are very common and are a major contributor to global antibiotic use and resistance. Without effective antibiotics active against common uropathogens, many urological procedures would carry excessive risk. In this arti...

Molecular genetics and clinical features of Birt–Hogg–Dubé syndrome

Birt–Hogg–Dubé (BHD) syndrome is an inherited renal cancer syndrome caused by germline mutations in the FLCN gene on chromosome 17. Manifestations include benign cutaneous fibrofolliculomas, bilateral pulmonary cysts and ...

The elementome of calcium-based urinary stones and its role in urolithiasis

The elementome—the full spectrum of elemental content—of urinary calculi is emerging as a new concept in stone research. Here, Ramaswamy et al. summarize current knowledge of the elementome of calcium-based urinary calculi and highlight study re...

Prostate cancer: No evidence for adjuvant chemotherapy in high-risk disease

The RTOG trial investigated the survival benefit of chemotherapy combined with androgen deprivation therapy (ADT) in patients with high-risk nonmetastatic prostate cancer after radiotherapy. However, the 10-year overall survival data showed no differ...

Stones: Gene variants associated with formation

Bladder cancer: Patient-derived murine xenografts

The past 10 years—new hormones, new functions, new endocrine organs

In this Viewpoint, six members of our Advisory Board comment on advances in the past 10 years that have revealed new hormones, new functions for known hormones and endocrine organs and new endocrine roles for well-known organs. The authors discuss ho...

News: Circulating irisin confirmed by mass spectrometry

Strategies to overcome the ABO barrier in kidney transplantation

The development of effective desensitization strategies has enabled ABO incompatible (ABOi) kidney transplantation to become an established treatment option for patients with end-stage renal disease. Here, the authors review the mechanisms that under...

Decade in Review—Genetics of kidney diseases: Genetic dissection of kidney disorders

Advances in genome sequencing and genetic manipulation techniques over the last decade have helped identify numerous single-gene causes of early-onset kidney diseases and risk alleles for complex, polygenic traits. Subsequent studies regarding the un...

AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer’s Disease

Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

Jian Yang and colleagues present a method, GREML-LDMS, to estimate heritability for complex human traits using whole-genome sequencing data or imputation with the 1000 Genomes Project reference panel. Using the heritability estimates from GREML-LDMS,...


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