Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

20:28 EDT 2nd August 2015 | BioPortfolio

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Showing News Articles 26–50 of 14,000+ from Nature Publishing

Friday 31st July 2015

Building stomach in a dish

Modelling organs in culture has great potential to improve our understanding of development, organogenesis and disease. While some endodermal derived organs have been modelled, the corpus region of the stomach, where acid-producing cells reside, rema...

Condensing chromosome condensation

Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now — 130 years later — chromatid condensation is reconstituted in vitro with the minimum components. The re...

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

Case and Waterman discuss how integrating extracellular-matrix-bound integrins and the actin cytoskeleton into a mechanosensitive molecular clutch transmits actin-cytoskeleton-generated forces to the extracellular matrix through focal adhesions.

Big opportunities for small molecules in immuno-oncology

Small-molecule drugs have several advantages that are complementary to, and possibly synergistic with, biologic approaches for anticancer immunotherapy. This Review provides an overview of immunological pathways that can best be targeted with small m...

Island colonisation and the evolutionary rates of body size in insular neonate snakes

Inflammation: NETting a one-two punch

Neutrophil extracellular traps (NETs) prime macrophages for interleukin-1β production in atherosclerosis.

Replaying evolutionary transitions from the dental fossil record

Gradual changes that occur to mammalian tooth morphology across evolutionary time were modelled in vitro and in vivo by modulation of signalling pathways in the mouse, and computer modelling was used to provide further analysis of the parameters infl...

Evolution: Tooth structure re-engineered

Mice deficient in the EDA protein lack normal tooth features. Restoring EDA in embryonic teeth at increasing doses has now been found to recover these dental features in a stepwise pattern that mimics evolution.

The Crohn’s disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects

G-protein-coupled receptor kinases in inflammation and disease

The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis

Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative

Relationship between blood pressure varıability and renal activity of the renin–angiotensin system

Thursday 30th July 2015

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

Tranexamic acid and blood loss during and after cesarean section: a meta-analysis

Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers

Changes in infant mortality among extremely preterm infants: US vital statistics data 1990 vs 2000 vs 2010

Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial

Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

Elevated plasma and cerebrospinal fluid interleukin-1 beta and tumor necrosis factor-alpha concentration and combined outcome of death or abnormal neuroimaging in preterm neonates with early-onset clinical sepsis

Intraplacental villous artery resistance indices and identification of placenta-mediated diseases

Certification figures and their accuracy

Certification figures and their accuracy Eye advance online publication, July 31 2015. doi:10.1038/eye.2015.143 Authors: A Quartilho, A Zekite, W Xing, M Loutfi, C Bunce & R Wormald

Month-6 primary outcomes of the READ-3 study (Ranibizumab for Edema of the mAcula in Diabetes—Protocol 3 with high dose)

Month-6 primary outcomes of the READ-3 study (Ranibizumab for Edema of the mAcula in Diabetes—Protocol 3 with high dose) Eye advance online publication, July 31 2015. doi:10.1038/eye.2015.142 Authors: D V Do, Y J Sepah, D Boyer, D Ca...


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