Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

17:39 EDT 29th April 2016 | BioPortfolio

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Showing News Articles 26–50 of 17,000+ from Nature Publishing

Thursday 28th April 2016

Osteoarthritis: Molecular imaging detects activated macrophages

Utility of neutrophil volume conductivity scatter (VCS) parameter changes as sepsis screen in neonates

Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia

Pathophysiology and management of multivalvular disease

Multivalvular disease is common among patients with valvular disease, and has a complex pathophysiology. In this Review, Unger et al. discuss the mechanisms, diagnosis, and percutaneous and surgical treatment of multivalvular disease, focusing on the combinations of valve pathologies that are most often encountered in clinical practice.

Wednesday 27th April 2016

Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption

A survey of people with inflammatory bowel disease to investigate their views of food and nutritional issues

Protein substitutes for phenylketonuria in Europe: access and nutritional composition

Body composition analysis by dual-energy X-ray absorptiometry in young preschool children

Outcome of intestinal failure after bariatric surgery: experience from a national UK referral centre

Demographic inference under a spatially continuous coalescent model

Improvement in nitrogen fixation capacity could be part of the domestication process in soybean

Dissection of allelic interactions among Pto-miR257 and its targets and their effects on growth and wood properties in Populus

Moderate genetic drift is driven by extreme recruitment events in the invasive mollusk Crepidula fornicata

The contribution of dominance to phenotype prediction in a pine breeding and simulated population

Molecular mechanism of APC/C activation by mitotic phosphorylation

In eukaryotes, the anaphase-promoting complex (APC/C, also known as the cyclosome) regulates the ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate chromosome segregation in mitosis and entry into the G1 phase. The catalytic activity of the APC/C and its ability to specify the destruction of particular proteins at different phases of the cell cycle are controlled by its ...

Resolved atomic lines reveal outflows in two ultraluminous X-ray sources

Ultraluminous X-ray sources are extragalactic, off-nucleus, point sources in galaxies, and have X-ray luminosities in excess of 3 × 1039 ergs per second. They are thought to be powered by accretion onto a compact object. Possible explanations include accretion onto neutron stars with strong magnetic fields, onto stellar-mass black holes (of up to 20 solar masses) at or in excess of the classi...

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many organisms and holds promise as a tool to generate models of human diseases, for example, in human pluripotent stem cells. CRISPR/Cas9 introduces targeted double-stranded breaks (DSBs) with high efficiency, which are typically repaired by non-homologous end-joining (NHEJ) resulting in nonspecific insertions, deletions or...

FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration

In salamanders, grafting of a left limb blastema onto a right limb stump yields regeneration of three limbs, the normal limb and two ‘supernumerary’ limbs. This experiment and other research have shown that the juxtaposition of anterior and posterior limb tissue plus innervation are necessary and sufficient to induce complete limb regeneration in salamanders. However, the cellular and molecula...

Iron(III)-catalysed carbonyl–olefin metathesis

The olefin metathesis reaction of two unsaturated substrates is one of the most powerful carbon–carbon-bond-forming reactions in organic chemistry. Specifically, the catalytic olefin metathesis reaction has led to profound developments in the synthesis of molecules relevant to the petroleum, materials, agricultural and pharmaceutical industries. These reactions are characterized by their use of ...

Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture

Circuits in the visual cortex integrate the information derived from separate ON (light-responsive) and OFF (dark-responsive) pathways to construct orderly columnar representations of stimulus orientation and visual space. How this transformation is achieved to meet the specific topographic constraints of each representation remains unclear. Here we report several novel features of ON–OFF conver...

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency virus type 1 (HIV-1) infection, little progress has been made in generating an effective HIV-1 vaccine. Although passive transfer of anti-HIV-1 broadly neutralizing antibodies can protect mice or macaques against a single high-dose challenge with HIV or simian/human (SIV/HIV) chimaeric viruses (SHIVs) respect...

Principles underlying sensory map topography in primary visual cortex

Recordings from cat visual cortex show that the cortical maps for stimulus orientation, direction and retinal disparity depend on an organization in which thalamic axons with similar retinotopy and light/dark responses are clustered together in the cortex.

Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance

Phage-assisted continuous evolution (PACE) rapidly evolves Bacillus thuringiensis toxins through more than 500 generations of mutation, selection, and replication to bind a receptor expressed on the surface of insect-pest midgut cells.

Regeneration: Limb regrowth takes two

Salamanders can regenerate several of their organs, including amputated limbs. Analysis of a Mexican salamander shows that crosstalk between two signalling molecules regulates limb regeneration.

Immunology: Mum's microbes boost baby's immunity

The microorganisms that colonize pregnant mice have been shown to prime the innate immune system in newborn offspring, preparing them for life in association with microbes.

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