Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

05:47 EDT 20th October 2014 | BioPortfolio

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Showing News Articles 26–50 of 25,000+ from Nature Publishing

Friday 17th October 2014

The generation of neutrophils in the bone marrow is controlled by autophagy

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

Unraveling the mechanism of cell death induced by chemical fibrils

A roadmap for natural product discovery based on large-scale genomics and metabolomics

Targeted protein destabilization reveals an estrogen-mediated ER stress response

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme

Chemomechanical coupling of human mitochondrial F1-ATPase motor

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

N6-methyladenosine (m6A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain family proteins. Here we present the crystal structures of the YTH domain of YTHDC1, ...

Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis

The tumor suppressor protein prostate apoptosis response-4 (Par-4), which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in...

A new family of iron-dependent halogenases acts on freestanding substrates

Regio- and stereospecific incorporation of a halogen atom to an unactivated sp3 carbon in a freestanding molecule is a challenging transformation that is currently missing in the inventory of enzyme-mediated reactions. Here we report what is to our k...

Combating neurodegenerative disease with chemical probes and model systems

The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis

Druggable sensors of the unfolded protein response

Energy landscapes of functional proteins are inherently risky

Vaccine development: NKT-cell adjuvants in conjugate

Two studies demonstrate that natural killer T-cell adjuvants, covalently attached to either carbohydrate or peptide epitopes, yield effective vaccines.

Protein trafficking: RESETting proteostasis

A recent study reveals a new cellular pathway that clears the endoplasmic reticulum of misfolded, GPI-anchored proteins at the onset of endoplasmic reticulum (ER) stress. This mechanism, termed rapid ER stress–induced export, represents a nontransc...

Protein homeostasis: Modeling UPR adaptive responses

Understanding the mechanisms that determine cell fate under endoplasmic reticulum (ER) stress had been hampered by the lack of models to study unfolded protein response (UPR) adaptive phases. The development of an engineered protein to conditionally ...

Enzymology: A radical finding

A new family of radical halogenases has been discovered that regio- and stereoselectively chlorinates the unactivated carbon center of indolemonoterpenoid substrates without the prerequisite for the substrate to be bound to a protein carrier.

Protein turnover: Mitochondrial immaturity

Target identification: NAD salvages neurons

Carbohydrates: Cutting out starch

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