Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

07:26 EDT 31st October 2014 | BioPortfolio

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Showing News Articles 26–50 of 26,000+ from Nature Publishing

Thursday 30th October 2014

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells

An eIF4E-interacting peptide induces cell death in cancer cell lines

A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium

TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival

Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus

Appreciating force and shape — the rise of mechanotransduction in cell biology

The form of vertebrates is shaped by the sensing and relaying of mechanical forces that are applied between cells and their microenvironment. Mechanobiology has emerged as a field of research dedicated to studying these forces and their communication...

Physical influences of the extracellular environment on cell migration

The physical properties of the extracellular environment — in terms of confinement, rigidity, surface topology and adhesion-ligand density — can have profound effects on the migration strategy and migration velocity of cells in different in vivo ...

Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors

Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multidrug-resistant tumors

High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs

Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese

An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer

Variations of the perforin gene in patients with chronic inflammatory demyelinating polyradiculoneuropathy

A cross-chiral RNA polymerase ribozyme

Thirty years ago it was shown that the non-enzymatic, template-directed polymerization of activated mononucleotides proceeds readily in a homochiral system, but is severely inhibited by the presence of the opposing enantiomer. This finding poses a se...

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Gastric diseases, including peptic ulcer disease and gastric cancer, affect 10% of the world’s population and are largely due to chronic Helicobacter pylori infection. Species differences in embryonic development and architecture of the adult stoma...

Tissue-specific clocks in Arabidopsis show asymmetric coupling

Many organisms rely on a circadian clock system to adapt to daily and seasonal environmental changes. The mammalian circadian clock consists of a central clock in the suprachiasmatic nucleus that has tightly coupled neurons and synchronizes other clo...

Solution-processed, high-performance light-emitting diodes based on quantum dots

Solution-processed optoelectronic and electronic devices are attractive owing to the potential for low-cost fabrication of large-area devices and the compatibility with lightweight, flexible plastic substrates. Solution-processed light-emitting diode...

Promoterless gene targeting without nucleases ameliorates haemophilia B in mice

Site-specific gene addition can allow stable transgene expression for gene therapy. When possible, this is preferred over the use of promiscuously integrating vectors, which are sometimes associated with clonal expansion and oncogenesis. Site-specifi...

The contribution of de novo coding mutations to autism spectrum disorder

Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to the incidence of simplex autism, with target gene...

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Genome-wide association studies combined with data from epigenomic maps for immune cells have been used to fine-map causal variants for 21 autoimmune diseases; disease risk tends to be linked to single nucleotide polymorphisms in cell-type-specific e...


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