Latest Biotechnology, Pharmaceutical and Healthcare News - Page: 2 from Nature Publishing

15:50 EST 28th February 2015 | BioPortfolio

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Showing News Articles 26–50 of 14,000+ from Nature Publishing

Friday 27th February 2015

Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs

Bagnat, Martín-Belmonte and colleagues reveal that plasmolipin (PLLP) is upregulated in the zebrafish midgut during development and controls epithelial patterning by promoting polarized endocytosis.

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation

Westlake and colleagues discover that membrane shaping EHD proteins participate in ciliogenesis by taking part in ciliary vesicle formation and transition zone protein recruitment.

Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice

Khokha and colleagues report that lack of the metalloproteinase inhibitors TIMP1 and TIMP3 in female mice increases the size of the mammary basal stem cell pool and that this is maintained in ageing mice.

Huntingtin facilitates selective autophagy

Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the indu...

Merlin's wizardry guides cohesive migration

Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-...

In vivo reprogramming for tissue repair

Berninger and colleagues define milestones for in vivo reprogramming and discuss recent developments in reprogramming into pancreatic b-cells and neurons.

Tipping the metabolic scales towards increased longevity in mammals

Riera and Dillin review how longevity is affected by metabolic changes and mitochondrial function.

Introducing double-blind peer review

Nature and its sister journals start offering anonymity to authors during the peer-review process.

Spotlight on Metabolism

In this issue, we present the first of a series of Reviews discussing different aspects of cell metabolism.

The ins and outs of MHC class II-mediated antigen processing and presentation

To play their part in the generation of effective adaptive immune responses, different types of antigen-presenting cell (APC) take up and process antigen in different ways. The length of time that peptide–MHC class II complexes are present on APC s...

Detection of dietary plant-based small RNAs in animals

A novel chemopreventive strategy based on therapeutic microRNAs produced in plants

The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells

Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells

Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush

p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

Mask ventilation with two different face masks in the delivery room for preterm infants: a randomized controlled trial

Does chronic oxygen dependency in preterm infants with bronchopulmonary dysplasia at NICU discharge predict respiratory outcomes at 3 years of age?

Evaluation of the performance of the insulin-like growth factor-binding protein-1/alpha-fetoprotein test in diagnosing ruptured fetal membranes in pregnant women

Thrombomodulin Promotes Diabetic Wound Healing by Regulating Toll-Like Receptor 4 Expression

Relative Expression of Proinflammatory and Antiinflammatory Genes Reveals Differences between Healing and Nonhealing Human Chronic Diabetic Foot Ulcers

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