Latest Biotechnology, Pharmaceutical and Healthcare News from The Lancet

09:18 EDT 25th September 2017 | BioPortfolio

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Showing News Articles 1–25 of 2,300+ from The Lancet

Friday 22nd September 2017

[Articles] Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial

Although combination treatment showed a significant decrease in viral shedding at day 3 relative to monotherapy, this difference was not associated with improved clinical benefit. More work is needed to understand why there was no clinical benefit when a difference in virological outcome was identified.

[Comment] Finding the right combination antiviral therapy for influenza

Influenza results in annual epidemics and global pandemics of acute respiratory illness that increases morbidity, mortality, and hospital admissions. Fortunately, there are currently two classes of antivirals licensed for the treatment of influenza in much of the world: the M2 inhibitiors (amantadine and rimantadine) and the neuraminidase inhibitors (oseltamivir, peramivir and zanamivir). There ar...

Thursday 21st September 2017

[News] Pyrotinib shows activity in metastatic breast cancer

Pyrotinib, an irreversible pan-ErbB inhibitor, shows promising antitumour activity in patients with HER2-positive metastatic breast cancer, according to the results of a recent phase 1 trial.

[Articles] The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study

Higher recreational and non-recreational physical activity was associated with a lower risk of mortality and CVD events in individuals from low-income, middle-income, and high-income countries. Increasing physical activity is a simple, widely applicable, low cost global strategy that could reduce deaths and CVD in middle age.

[Comment] Physical activity lowers mortality and heart disease risks

In The Lancet, Scott A Lear and colleagues1 report results from a large cohort of 130 843 participants from 17 countries (including four low-income countries and seven middle-income countries) investigating the beneficial dose-dependent associations of all forms of physical activity with reduced mortality and cardiovascular disease risks.1 This is another confirmation that physical activity has ...

[Comment] Ethnic cleansing in Myanmar: the Rohingya crisis and human rights

A humanitarian crisis of enormous scale and scope is unfolding in western Myanmar's Rakhine State and its border zone with Bangladesh. More than 420 000 Rohingya women, children, and men have fled widespread violence in Rakhine State in the past 3 weeks.1 Some 240 000 of them are children, according to UNICEF.2

Wednesday 20th September 2017

[Comment] Scratching the itch: is scabies a truly neglected disease?

Human scabies is a parasitic skin disease that affects people worldwide. To improve public-health decision making, measurement of the global burden of scabies is key. In this issue of The Lancet Infectious Diseases, Chante Karimkhani and colleagues1 report a cross-sectional analysis of the Global Burden of Disease (GBD) 2015 big data to show a robust estimate of the extent and impact of this ubiqu...

[Articles] The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015

The burden of scabies is greater in tropical regions, especially in children, adolescents, and elderly people. As a worldwide epidemiological assessment, GBD 2015 provides broad and frequently updated measures of scabies burden in terms of skin effects. These global data might help guide research protocols and prioritisation efforts and focus scabies treatment and control measures.

[Articles] Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

Over 2 years, more frequent donation than is standard practice in the UK collected substantially more blood without having a major effect on donors' quality of life, physical activity, or cognitive function, but resulted in more donation-related symptoms, deferrals, and iron deficiency.

[Comment] The price of blood is measured in iron

Volunteer blood donors give about 500 mL of whole blood, approximately 10% of their total blood volume. After removal of plasma during processing, each mL of packed red blood cells contains 1 mg of iron. Thus, 200–250 mg iron are removed from the donor at each donation depending on their haematocrit. Since average iron stores are only 250 mg in women and 1000 mg in men, repeated donation produce...

Tuesday 19th September 2017

[Articles] Changes in cause-specific neonatal and 1–59-month child mortality in India from 2000 to 2015: a nationally representative survey

To meet the 2030 Sustainable Development Goals for child mortality, India will need to maintain the current trajectory of 1–59-month mortality and accelerate declines in neonatal mortality (to >5% annually) from 2015 onwards. Continued progress in reduction of child mortality due to pneumonia, diarrhoea, malaria, and measles at 1–59 months is feasible. Additional attention to low birthweight i...

[Correspondence] Health professional education on trafficking: the facts matter

As physician leaders of HEAL Trafficking, we were delighted to see human trafficking framed as a health-care issue in The Lancet Editorial “Health providers—helping to disrupt human trafficking” (Aug 5, p 532).1 However, we were dismayed to see the tragic San Antonio case referenced definitively as human trafficking. Smuggling entails helping people cross borders undetected for a fee, wherea...

[Comment] Child mortality: the challenge for India and the world

Earlier this year, one of us took part in a policy dialogue about child health in Bangladesh. On being presented with evidence of increasing mortality among children younger than 5 years in parts of Bangladesh, a senior government official rightly enquired whether or not disaggregated (regional) cause of death data had been collected that could help explain this deviation from the national trend a...

Monday 18th September 2017

[Comment] The NCDs Cooperative: a call to action

Over the past 20 years, decision makers have largely stood impotent as non-communicable diseases (NCDs) have exploded around the world. Without a dramatic change in strategy, this resounding collective failure will persist. As I travelled the globe as one of three nominees for the Director-General of WHO, I met with 191 country delegations, including heads of state, foreign ministers, and health m...

Sunday 17th September 2017

[Global Health Metrics] Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expert...

[Comment] Global burden of neurological disease: what's in a name?

We are living in a rapidly changing landscape in terms of global public health. On one hand, the immense increase in and ageing of the world's population, mass migration of people from rural to urban areas, and unhealthy lifestyles—either by choice or by circumstance—are negatively affecting the overall health of the planet. On the other hand, medical advances such as vaccines, antibiotics, an...

[Comment] Where is the accountability to adolescents?

Accountability is a loaded concept. For many, the term itself has negative and punitive connotations. When it comes to accountability to adolescents—who number 1·2 billion today1—discourse is rare. Adolescents are the central promise for accelerated, lasting progress on the Global Strategy for Women's, Children's and Adolescents' Health2 and the Sustainable Development Goals (SDGs). But for a...

Friday 15th September 2017

[Seminar] Hyperparathyroidism

Primary hyperparathyroidism is a common endocrine disorder of calcium metabolism characterised by hypercalcaemia and elevated or inappropriately normal concentrations of parathyroid hormone. Almost always, primary hyperparathyroidism is due to a benign overgrowth of parathyroid tissue either as a single gland (80% of cases) or as a multiple gland disorder (15–20% of cases). Primary hyperparathyr...

[Viewpoint] California Universal Health Care Bill: an economic stimulus and life-saving proposal

On June 1, 2017, the California Senate approved a bill (Senate Bill 562) to establish universal single-payer health care for all residents. This state legislation comes in the midst of federal proposals to repeal and replace the Affordable Care Act, which are anticipated to almost double the number of uninsured Americans to 51 million in a decade.1 Uninsured individuals have a 40% increased risk o...

[The Lancet Commissions] The path to longer and healthier lives for all Africans by 2030: the Commission on the future of health in sub-Saharan Africa

Sub-Saharan Africa's health challenges are numerous and wide-ranging. Most sub-Saharan countries face a double burden of traditional, persisting health challenges, such as infectious diseases, malnutrition, and child and maternal mortality, and emerging challenges from an increasing prevalence of chronic conditions, mental health disorders, injuries, and health problems related to climate change a...

[News] Immune response boosted in metastatic colorectal cancer

Low-dose cyclophosphamide and modified vaccinia Ankara–5T4 might both improve antitumour immune responses and prolong survival in patients with metastatic colorectal cancer, new research suggests.

[News] ESMO 2017 Congress

The radiolabelled small molecule lutetium-177 (177Lu)-PSMA617 can target radiotherapy to prostate-specific membrane antigen-positive prostate cancer cells. In a phase 2 trial led by Michael Hofman (Peter MacCallum Cancer Centre, Melbourne, VIC, Australia), 30 patients with PSMA-avid refractory metastatic castration-resistant prostate received up to four cycles of LuPSMA every 6 weeks. The coprimar...

[Articles] Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial

Use of CGM during pregnancy in patients with type 1 diabetes is associated with improved neonatal outcomes, which are likely to be attributed to reduced exposure to maternal hyperglycaemia. CGM should be offered to all pregnant women with type 1 diabetes using intensive insulin therapy. This study is the first to indicate potential for improvements in non-glycaemic health outcomes from CGM use.

[Comment] Continuous glucose monitoring in pregnant women with type 1 diabetes

The use of continuous glucose monitoring (CGM) has been increasing, especially in patients with type 1 diabetes, partly due to improved accuracy with lower mean amplitude relative difference (about 10%) with the newer or implantable sensors.1,2 Most real-time subcutaneous sensors are approved for 7 days—except for the implantable sensor, which lasts 3 months—and require two calibrations per da...

Thursday 14th September 2017

[Articles] Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

Xpert Ultra detected significantly more tuberculous meningitis than did either Xpert or culture. WHO now recommends the use of Xpert Ultra as the initial diagnostic test for suspected tuberculous meningitis.

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