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07:04 EDT 20th September 2017 | BioPortfolio

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Showing News Articles 1–25 of 35,000+ from Nature Publishing

Tuesday 19th September 2017

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

The N6-methyladenosine (m6A) modification in mRNAs, generated by the enzyme METTL3, controls normal human hematopoietic stem/progenitor cell differentiation and maintains the undifferentiated leukemic phenotype of human acute myeloid leukemia cells.

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

Treatment with tyrosine kinase inhibitors results in a survival benefit in patients with chronic myeloid leukemia (CML). However, relapse due to persistent leukemic stem cells (LSCs) requires additional selective targets for efficient eradication of the disease. Metabolomic analyses on patient-derived CML LSCs reveal that these have an increased dependency on oxidative metabolism that renders them...

Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma

A silent single-nucleotide variant (SNV) affecting the transcription of a long noncoding RNA (lncRNA EGFR-AS1) within the EGFR coding region alters the EGFR isoform ratio and modulates oncogene addiction and response to EGFR tyrosine kinase inhibitors in squamous-cell cancers. Proof-of-concept validation in patients supports the notion that this SNV and levels of the lncRNA could be used to predic...

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

Factors secreted by metastatic a primary tumors induce an early phenotypic switch in perivascular cells at distant pre-metastatic niches. By using sophisticated lineage-tracing mouse models, the authors demonstrate that enhanced KLF4 expression in these cells increases their ability to proliferate and migrate away from the vasculature, and augments fibronectin deposition, which contributes to meta...

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

Transcriptomic profiling using a newly-developed cre-inducible method to biotinylate wild-type and mutant MeCP2 protein highlights the cellular heterogeneity of transcriptional changes in rodent models of Rett Syndrome, including cell-type- and subcellular compartment-specific differences in male brains and X-linked mosaicism in female brains.

Interleukin-7 in the transition of bone marrow progenitors to the thymus

Writer’s block: preventing m6A mRNA methylation promotes T cell naivety

Modeling primary immune regulatory disorders: Ferrari or Yugo?

Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: a classical twin study

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

Excessive body fat linked to blunted somatosensory cortex response to general reward in adolescents

Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study

Prenatal antimicrobial use and early-childhood body mass index

Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner

Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss

Liver volume and hepatic adiposity in childhood: relations to body growth and visceral fat

Birthweight and cardiometabolic risk patterns in multiracial children

Metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (Microcebus murinus)

Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life

Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population

The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study

Prostate cancer: Potential of PARP inhibition plus ADT in prostate cancer

Bladder cancer: Shields up, red alert: the blebbishield emergency programme

Transplantation: CXCL10 linked to poor outcomes

Surgery: Postprandial hypoglycaemia following bariatric surgery

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