Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
14:23 EDT 23 Jul 2012 | Nature Publishing
Here the authors show that the binding of amyloid-β (Aβ) oligomers to cellular prion protein (PrPc) activates Fyn kinase. Aβ stimulation of PrPc/Fyn signaling drives phosphorylation of the NR2B subunit of NMDA receptors, with a subsequent loss of..
Original Article: Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
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