Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
17:38 EDT 15 Aug 2012 | Nature Publishing
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5+ ste..
Original Article: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
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