Controlling cell-fate decisions

03:00 EDT 23 Sep 2016 | Medical Xpress

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial for cell-fate decisions. While this study has important implications for normal development and tissue homeostasis, it also provides insights into the origin of certain diseases associated with abnormal Notch signaling, such as acute T cell leukemia.

Original Article: Controlling cell-fate decisions


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