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Evaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells

20:00 EDT 17 Oct 2016 | BioMed Central

Methylated CpG dinucleotides in promoters are associated with the loss of gene expression in recombinant Chinese hamster ovary (CHO) cells during large-scale commercial manufacturing. We evaluated a promoter d...

Original Article: Evaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells

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