Track topics on Twitter Track topics that are important to you
The benefits of the CRISPR/Cas9 system for use in directly targeting mutations of genetic disorders has been reported widely over the past several years. However, another advantage of this genome-editing technique is the ability to utilize it as a screening tool for drug development—which is exactly what researchers from the Wellcome Trust Sanger Institute and their collaborators have done to find new therapeutic targets for acute myeloid leukemia (AML). The investigators were able to identify a significant number of genes that could serve as potential targets for anti-AML treatments. Moreover, the Sanger team described how inhibition of one of the genes they found—KAT2A—destroys AML cells without harming nonleukemic blood cells. The findings from this new study were published recently in Cell Reports in an article entitled “A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.” AML is an aggressive cancer that proliferates ...
Original Article: CRISPR Screen Finds New Potential Leukemia Drug TargetNEXT ARTICLE
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...
Leukemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases. In turn, it is part of the even broader grou...