CRISPR Screen Finds New Potential Leukemia Drug Target

06:55 EDT 19 Oct 2016 | Genetic Engineering News

The benefits of the CRISPR/Cas9 system for use in directly targeting mutations of genetic disorders has been reported widely over the past several years. However, another advantage of this genome-editing technique is the ability to utilize it as a screening tool for drug development—which is exactly what researchers from the Wellcome Trust Sanger Institute and their collaborators have done to find new therapeutic targets for acute myeloid leukemia (AML). The investigators were able to identify a significant number of genes that could serve as potential targets for anti-AML treatments. Moreover, the Sanger team described how inhibition of one of the genes they found—KAT2A—destroys AML cells without harming nonleukemic blood cells. The findings from this new study were published recently in Cell Reports in an article entitled “A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.” AML is an aggressive cancer that proliferates ...

Original Article: CRISPR Screen Finds New Potential Leukemia Drug Target


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