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PUBLICATION EXCLUSIVE: Differentiation of wet AMD and PCV is crucial

15:30 EST 1 Dec 2016 | Healio

Most patients who present with painless, progressive loss of vision and metamorphopsia, with evidence of subretinal hemorrhages and exudates in the macular area on fundus examination, have wet or exudative age-related macular degeneration.Experienced clinicians know that, in the U.S., horses are much more common in the countryside than zebras, and wet AMD is a horse, not a zebra. The same clinicians also know that zebras occasionally present in their clinics, and polypoidal choroidal vasculopathy (PCV), first described by Dr. Lawrence Yannuzzi in 1982, is one of the zebras to rule out in the patient who presents with a clinical course and findings consistent with wet AMD. Other conditions that belong in the differential diagnosis of wet AMD include central serous chorioretinopathy, ocular histoplasmosis syndrome, pathologic myopia, choroidal injury, angioid streaks and, perhaps, Best’s vitelliform maculopathy and Stargardt disease.

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