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Rapid and accurate on‐site wireless measurement of hazardous molecules or biomarkers is one of the biggest challenges in nanobiotechnology. We herein describe a novel smartphone‐based Portable and Wireless Optical System (PAWS) for rapid, quantitative, and on‐site analysis of target analytes. As a proof‐of‐concept, we employed gold nanoparticles (GNP) and an enzyme, horse radish peroxidase (HRP), to generate colorimetric signals in response to two model target molecules, melamine and hydrogen peroxide, respectively. The colorimetric signal produced by the presence of the target molecules is converted to an electrical signal by the inbuilt electronic circuit of the device. The converted electrical signal is then measured wirelessly via multimeter in the smartphone which processes the data and displays the results, including the concentration of analytes and its significance. This handheld device has great potential as a programmable and miniaturized platform to achieve rapid and on‐site detection of various analytes in a point‐of‐care testing (POCT) manner.NEXT ARTICLE
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...