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Salinomycin kills cancer stem cells by sequestering iron in lysosomes

04:37 EDT 16 May 2017 | Nature Publishing

Cancer stem cells are typically refractory to conventional treatments. Now, an unprecedented mechanism has been discovered by which salinomycin and derivatives can sequester iron in lysosomes leading to cytoplasmic iron depletion and the subsequent production of reactive oxygen species that are lethal to the cell. This discovery of the importance of iron in cancer stem cell maintenance provides an opportunity for developing new therapeutics.

Original Article: Salinomycin kills cancer stem cells by sequestering iron in lysosomes

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