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Analysis of pathways activation landscape in oral squamous cell carcinoma and pre-neoplastic lesions

20:00 EDT 5 Jun 2017 | AAAS

(InSilico Medicine, Inc.) Oral dysplastic lesions are considered precursors of OSCC. However only a subset of such lesions progress to invasive cancer. There is an urgent need for biomarkers, which might assign a risk for cancer development in patients with premalignant lesions. Scientists at the Johns Hopkins University alongside collaborators from Insilico Medicine, Inc, have applied iPANDA, a novel approach for analyzing high-throughput transcriptomic datasets, to identify the earliest signaling harbingers of malignant transition.

Original Article: Analysis of pathways activation landscape in oral squamous cell carcinoma and pre-neoplastic lesions

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