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CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations

09:23 EDT 6 Jun 2017 | Nature Publishing

Early STOP codons created with CRISPR base editors leads to gene knockout with high efficiency and does not stress cells with double-strand DNA breaks. CRISPR-STOP can target the majority of human genes and is useful for genetic screens.

Original Article: CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations

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