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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

10:15 EDT 6 Jun 2017 | Nature Publishing

Crystal structures of hGPR40, a target for treatment of type 2 diabetes, bound to a partial and an allosteric agonist explain the binding cooperativity between these ligands and present new opportunities for structure-guided drug design.

Original Article: Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

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