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CytomX Wins $15M Milestone Payment from AbbVie for Cancer Probody-Drug Conjugate

05:23 EDT 29 Jun 2017 | Genetic Engineering News

CytomX Therapeutics said today it will receive a $15 milestone payment from AbbVie for advancing a cancer-fighting Probody™ drug conjugate being developed by the companies into GLP toxicology studies toward filing an Investigational New Drug (IND) application next year. CX-2029 is a PDC designed to target CD71, also known as transferrin receptor 1 (TfR1), on tumor cells while sparing healthy cells by localizing the drug candidate’s activity primarily to cancer tissue. CD71 is highly and homogeneously expressed on many solid and blood tumor types. While that would make CD71 an ideal target for antibody drug conjugate strategies, the target is present on most normal cells—a challenge the companies say can be addressed by developing a therapeutic based on CytomX’s Probody platform. Probody therapeutics are designed to remain inactive until they are activated by proteases in the tumor microenvironment. According to CytomX, the therapeutics bind selectively to ...

Original Article: CytomX Wins $15M Milestone Payment from AbbVie for Cancer Probody-Drug Conjugate

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