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Structure of a pre-catalytic spliceosome

10:45 EDT 29 Jun 2017 | Nature Publishing

Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome’s catalytic centre. Here we report the cryo-electron microscopy structure of the yeast Saccharomyces cerevisiae pre-catalytic B complex spliceosome at near-atomic resolution. The mobile U2 small nuclear

Original Article: Structure of a pre-catalytic spliceosome

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