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[Comment] Androgen deprivation in prostate cancer: first do no harm

19:09 EDT 29 Jul 2017 | The Lancet

The use of androgen-deprivation therapy for treatment of non-metastatic, recurrent prostate cancer after local therapy is heavily debated, given the risks of treatment for the sake of controlling a disease that might not lead to life-threatening consequences. Findings from studies done almost 20 years ago had shown the survival benefits of early initiation of androgen-deprivation therapy compared with waiting for the appearance of symptoms or metastatic spread.1–3 Most of these landmark studies were done before the availability of testing for prostate-specific antigen (PSA), but nevertheless lead to widespread use of androgen-deprivation therapy in early, biochemically recurrent disease following local therapy.

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