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RNA-Seq Used to Discriminate between Bacterial and Viral Infections

06:43 EDT 31 Jul 2017 | Genetic Engineering News

The ability of clinicians to discriminate between bacterial and viral infections among their patients is critical, not only to administer the appropriate therapeutic intervention but to help quell the rise in a major global health threat—antibiotic resistance stemming from overuse. Unfortunately, ailments such as lower respiratory tract infections (LRTI) symptomatically present with similar clinical symptoms, regardless of the root pathogen—making proper diagnosis difficult. Now, investigators at the University of Rochester Medical Center (URMC) have recently released finding from a new study that utilized the power of RNA sequencing (RNA-Seq) and transcriptomic analysis to help physicians prescribe antibiotics to patients who need them, and avoid giving them to individuals who don't. Results from the new study were published recently in Scientific Reports through an article entitled “ Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness .” “It's extremely difficult to interpret what's ...

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