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Global profiling of lysine reactivity and ligandability in the human proteome

03:29 EDT 1 Aug 2017 | Nature Publishing

A chemical proteomic strategy has now been reported for the global profiling of lysine reactivity and ligandability. Using this approach, >9000 lysines in the human proteome were evaluated, leading to the discovery of hyper-reactive lysines, and lysines that can be targeted by electrophilic small molecules to perturb enzyme function and protein–protein interactions.

Original Article: Global profiling of lysine reactivity and ligandability in the human proteome

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