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Increased α5β1 integrin could improve tumor cell-killing performance in geriatric patients

07:22 EDT 1 Aug 2017 | Medical Xpress

A new report in the Journal of Leukocyte Biology describes an important step toward developing cancer treatments involving the body's immune system. Specifically, chimeric antigen receptor T cell (CAR-T) therapy involves collecting white blood cells from patients and re-engineering them into potent cancer-killing agents. This report showed that CAR-T cells from geriatric donors have specific defects that lead to decreased tumor cell-killing performance, when compared to younger donors. The study also uncovered the Geri-T method, which increases α5β1 integrin expression to reverse age-related CAR-T dysfunction.

Original Article: Increased α5β1 integrin could improve tumor cell-killing performance in geriatric patients

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