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In Reply Dr Scheer and colleagues raise 2 concerns about our study. First, we agree that α2-agonists should have positive effects on the sympatholytic condition, which might result in improved clinical outcomes with the dexmedetomidine strategy. Although 28-day mortality in our study did not reach statistical significance, the effect, if any, of α2-agonists on the sympatholytic condition in patients with sepsis might have contributed to the absolute mortality difference of 8%.NEXT ARTICLE
Sepsis, septicaemia and blood poisoning
Septicaemia (another name for blood poisoning) refers to a bacterial infection of the blood, whereas sepsis can also be caused by viral or fungal infections. Sepsis is not just limited to the blood and can affect the whole body, including the organ...