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Dexmedetomidine in Patients With Sepsis Requiring Mechanical Ventilation—Reply

20:00 EDT 31 Jul 2017 | JAMA

In Reply Dr Scheer and colleagues raise 2 concerns about our study. First, we agree that α2-agonists should have positive effects on the sympatholytic condition, which might result in improved clinical outcomes with the dexmedetomidine strategy. Although 28-day mortality in our study did not reach statistical significance, the effect, if any, of α2-agonists on the sympatholytic condition in patients with sepsis might have contributed to the absolute mortality difference of 8%.

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