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The lipid-binding side of Notch ligands

06:39 EDT 2 Aug 2017 | Nature Publishing

Notch signaling is adjusted to different physiological contexts by expression patterns of Notch ligands and receptors, as well as by posttranslational modifications that modulate the ligand/receptor affinity. In this issue of The EMBO Journal, Suckling et al (2017) show that an interaction of Notch ligands with membrane lipids promotes Notch binding and activation, thus proposing a new mode of Notch activity regulation.

Original Article: The lipid-binding side of Notch ligands

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