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Genetically engineered skin cells grafted onto mice can treat the animals’ diabetes and obesity, according to new research published August 2, 2017 in Cell Stem Cell . Researchers edited skin stem cells from newborn mice using CRISPR -based technology so that the cells secreted a peptide that regulates blood sugar. Transplanting the cells onto mice showed the grafts increased insulin secretion and reversed weight gain from a high-fat diet, as well as overturned insulin resistance. The result is a small step toward developing a safe and durable gene therapy to treat diabetes in humans. “We’ve had this idea for a long time, so it’s exciting to see that, indeed, it can work to deliver therapeutics,” coauthor Xiaoyang Wu , a stem cell biologist at the University of Chicago, tells GEN . In the study, Wu and colleagues worked with skin because it is a large ...
Original Article: CRISPR Gene Therapy via Skin Grafts Treats Obesity and Diabetes in MiceNEXT ARTICLE
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...
Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...