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Patient-reported outcomes seen as poor predictors of disease activity change for RA

15:40 EDT 3 Aug 2017 | Healio

Patient-reported outcomes, like pain, fatigue and stiffness, were minimally useful as predictors of rate changes in disease activity and disability in patients with rheumatoid arthritis, according to findings of this study.esearchers evaluated data from the Yorkshire Early Arthritis Register (YEAR), an observational inception cohort of adult patients diagnosed with recent-onset rheumatoid arthritis (RA). Researchers identified 1,415 patients enrolled in the YEAR between 1997 and 2009. Eligible participants also were required to have inflammatory symptoms lasting at least 24 months and have initiated treatment with disease-modifying antirheumatic drugs (DMARDs). At the start of data collection in 1997, the first-line DMARD was sulfasalazine. This changed to methotrexate when the data collection and treatment protocols were revised in 2002.Data were culled from baseline to 1 year. Researchers constructed multilevel models to evaluate baseline DAS-28 and health assessment questionnaire (HAQ-DI), as well as changes in these measures at 12 months. The model included conventionally reported predictors of RA outcome, such as sex, antibody status and age, as well as patient-reported pain, fatigue and duration of early-morning stiffness (EMS).

Original Article: Patient-reported outcomes seen as poor predictors of disease activity change for RA

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