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Image Analysis Tool Predicts Long-Term Recurrence of Breast Cancer

05:19 EDT 4 Aug 2017 | Genetic Engineering News

Scientists at the Institute for Cancer Research (ICR) in the U.K. have developed a computer tool that can predict the likelihood of breast cancer recurrence within 10 years of treatment, in women with the most common, estrogen receptor-positive (ER+) form of the disease. The image analysis system is used with routinely collected tumor samples, to look specifically for clusters, or ‘hotspots’ of tumor infiltrating lymphocytes (TILs), which can’t be detected readily by using a microscope. The results from tests with the new system are reported today in the Journal of the National Cancer Institute , in a paper entitled “Relevance of Spatial Heterogeneity of Immune Infiltration for Predicting Risk of Recurrence After Endocrine Therapy of ER+ Breast Cancer.” The researchers, led by Dr. Yinyin Yuan, say the results indicate that different immunosuppressive mechanisms are at work in ER+ and ER- forms of breast cancer. The findings may also ...

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