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Drug zeroes in on mutated nuclear receptors found in cancer, leaves normal proteins alone

10:43 EDT 4 Aug 2017 | Medical Xpress

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have published a study in Nature Communications shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth. Because the PI3K pathway is common to many cancers, K-80003 could have broad therapeutic applications. Tarrex Biopharma, Inc. has licensed the compound and announced they will soon begin Phase 1 clinical trials at the Dana Farber Cancer Center for patients with colorectal cancer.

Original Article: Drug zeroes in on mutated nuclear receptors found in cancer, leaves normal proteins alone

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