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Study offers road map to personalized therapies for sarcoma, other aggressive cancers

02:23 EDT 7 Aug 2017 | Medical Xpress

Sarcoma is a rare and deadly form of cancer occurring in the bones and connective tissue that affects people of all ages. Its aggressiveness, rarity and diversity continue to hinder efforts to identify effective therapies for people with this malignancy. In a patient-derived orthotopic xenograft, human tumor fragments are transplanted into a mouse. Such xenografts have long shown great promise in modeling how sarcoma and other cancers can respond to and resist therapies, but their feasibility for use in people in clinical settings remains unknown.

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