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Alzheimer’s Linked to Flaw in Lysosome Transport

06:58 EDT 7 Aug 2017 | Genetic Engineering News

The accumulation of extracellular plaque is not the only neuropathological manifestation of Alzheimer’s disease. The degenerative condition is also marked by axonal swelling, which is caused by the intracellular accumulation of lysosomes. It is not clear, however, how axons, the parts of neurons that conduct electric impulses, come to be packed with lysosomes. Neither is it clear how lysosome accumulation may be related to disease. Both of these questions, however, are a little less puzzling now that Yale University researchers have completed a study on lysosome transport. The researchers explored the possibility is that lysosomes promote plaque buildup, the aggregation of β-amyloid (Aβ) fragments, because some of the enzymes that generate Aβ by cleaving a protein called amyloid precursor protein (APP) accumulate in the swellings with the immature lysosomes. When the researchers worked with a mouse model of impeded lysosome transport, they found that neurons that lacked ...

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