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Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria

04:02 EDT 8 Aug 2017 | Nature Publishing

In echinoderm mitochondria, the codon AAA encodes asparagine instead of lysine. A newly identified nucleoside modification, hydroxy-N6-threonylcarbamoyladenosine (ht6A), is found adjacent to the anticodon in mt-tRNALys and prevents mt-tRNALys from misreading AAA as lysine.

Original Article: Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria

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