Advertisement

Topics

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

04:02 EDT 8 Aug 2017 | Nature Publishing

The activities of human holophosphatases R15A–PP1 and R15B–PP1 on substrate eIF2α are now reconstituted in vitro, revealing that inhibitors Guanabenz and Sephin1 induce a selective conformational change in R15A and impair the recruitment of eIF2α.

Original Article: Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

NEXT ARTICLE

More From BioPortfolio on "Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors"

Quick Search
Advertisement