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Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

04:02 EDT 8 Aug 2017 | Nature Publishing

Structural insight into TIR-domain interactions, which are essential for the recruitment of signaling adapters to Toll-like receptors during innate immune responses, demonstrates a conserved interaction mode involved in both TLR and IL-1R signaling.

Original Article: Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

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