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Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals

05:30 EDT 8 Aug 2017 | Nature Publishing

Although samarium-mediated cyclizations have the potential to generate significant molecular complexity, historically it has not proven possible to exert enantiocontrol through the use of a chiral ligand in complex product synthesis. Now, an enantioselective SmI2-mediated radical cyclization has been developed using a chiral aminodiol ligand. Desymmetrizing 5-exo ketyl-alkene cyclizations and cyclization cascades of unsaturated ketoesters deliver complex products and typically proceed with high enantioselectivity and diastereoselectivity.

Original Article: Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals

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