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Kite Pharma Submits IND for BCMA-Targeting CAR-T Cancer Immunotherapy

05:41 EDT 8 Aug 2017 | Genetic Engineering News

Kite Pharma said today it has submitted to the FDA an Investigational New Drug (IND) application to launch a Phase I, first-in-human trial of a CAR-T cell therapy that targets B-cell maturation antigen (BCMA) in patients with relapsed/refractory multiple myeloma. KITE-585 is designed to work through the engineering of a patient's T cells to express a chimeric antigen receptor (CAR) that targets BCMA, a protein expressed on the cell surface of multiple myelomas, then redirecting those T cells to kill cancer cells. KITE-585 contains a receptor derived from a fully human monoclonal antibody and a CD28 costimulatory domain intended for optimized T-cell expansion and function. Kite disclosed its intent to advance KITE-585 into the clinic in April, when it presented preclinical data on the CAR-T cell therapy at the American Association of Cancer Research (AACR) Annual Meeting in Washington D.C. In one study—Abstract #4979, “Development of ...

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