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Dermira Gains Rights to Roche IL-13 Inhibitor Lebrikizumab in Up-to-$1.4B Partnership

06:42 EDT 8 Aug 2017 | Genetic Engineering News

Dermira said today it has agreed to obtain exclusive, worldwide rights from Roche and its Genentech subsidiary to develop and commercialize lebrikizumab, a monoclonal antibody targeting interleukin 13 (IL-13), for most indications, in a deal that could generate up to $1.4 billion for the pharma giant. Under the companies’ licensing agreement, Dermira will gain rights to lebrikizumab in atopic dermatitis and all other indications except interstitial lung diseases, such as idiopathic pulmonary fibrosis—indications to which Roche will retain rights. Roche tried and failed last year to advance lebrikizumab in asthma, acknowledging disappointing results from two Phase III trials in February 2016. The LAVOLTA II trial missed its primary endpoint by showing rates of asthma exacerbations in people with higher levels of serum periostin or blood eosinophils that were not statistically significant. However, the LAVOLTA I trial met its primary endpoint, showing a significant reduction in the ...

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