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Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity

06:10 EDT 9 Aug 2017 | Nature Publishing

Galeterone is a steroid 17-α-hydroxylase/17,20 lyase and androgen receptor antagonist intended for patients with prostate cancer. Similar to abiraterone, galeterone has a steroid scaffold structure and mimics natural ligands; thus, these agents are metabolized by the same enzymes that synthesize or degrade naturally occurring steroids, which can result in attenuated efficacy.

Original Article: Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity

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