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Cancer Research UK, Biotecnol to Advance Solid Tumor Immunotherapy Into the Clinic

15:15 EDT 9 Aug 2017 | Genetic Engineering News

Cancer Research UK and Biotecnol said they will advance an immuno-oncology treatment for lung cancers and other solid tumors into early phase clinical trials, through a collaboration whose value was not disclosed. Cancer Research UK will support early clinical development of Biotecnol’s first-in-class drug Tb535H. The anti-5T4 pan-cancer T-cell engager is designed to work by recruiting the patient’s T-cells and directing them to attack tumors by targeting the 5T4/WAIF1 tumor antigen, a protein thought to contribute to the spread of cancer cells, and found on numerous solid tumors. Biotecnol and Cancer Research UK’s Centre for Drug Development will partner to advance Tb535H through a Biotecnol-sponsored first-in-humans Phase I clinical trial, using Cancer Research UK’s drug development expertise in return for a stake in Biotecnol. The WAIF1 antigen was discovered by researchers at the Cancer Research UK Manchester Institute. While it could prove a valuable target against ...

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