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[Comment] Nodal status and survival in anal cancer

21:33 EDT 9 Aug 2017 | The Lancet

In The Lancet Oncology, Hema Sekhar and colleagues1 describe a well designed, large-scale systematic review and meta-regression in anal cancer and their observation of an interesting phenomenon in stage migration and its effect on overall survival. After reviewing 62 studies that included more than 10 000 patients with anal cancer, the investigators noted a progressive increase in the proportion of patients with more advanced disease over time, particularly with the detection of more lymph-node positive disease.

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