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[Articles] Nodal stage migration and prognosis in anal cancer: a systematic review, meta-regression, and simulation study

21:33 EDT 9 Aug 2017 | The Lancet

We describe a consequence of staging misclassification in anal cancer that we have termed reduced prognostic discrimination. We used this new observation to infer that the LNP proportions of more than 30% seen in modern clinical series (11 out of 15 studies with a median year since 2007) are higher than the true LNP proportion. The introduction of new staging technologies in oncology might misclassify true disease stage, spuriously informing disease management and ultimately increasing the risk of overtreatment.

Original Article: [Articles] Nodal stage migration and prognosis in anal cancer: a systematic review, meta-regression, and simulation study

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