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Mitochondrial diseases: the contribution of organelle stress responses to pathology

05:54 EDT 10 Aug 2017 | Nature Publishing

Mitochondrial disorders encompass a broad range of pathologies, which manifest in different tissues, with variable age of onset and symptoms. Recent findings suggest that mitochondrial stress responses, which are activated by defects in mitochondrial genome maintenance and expression, contribute to cell and systemic dysfunction, and could explain the phenotypic variability of mitochondrial disorders.

Original Article: Mitochondrial diseases: the contribution of organelle stress responses to pathology

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