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Gene Study Based on RNA Interference May Lead to New Liver Cancer Therapies

05:11 EDT 11 Aug 2017 | Genetic Engineering News

University of Maryland researchers think they've discovered how a specific gene plays a key role in helping liver cancer cells obtain the nutrition necessary to proliferate. Their study (“Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells”) appears in  the  Journal of Biological Chemistry . Cancer is often treated by starving it by targeting the pathways cancer cells use to meet their energy needs. Hongbing Wang's. Ph.D.,  laboratory focuses on this approach in as it applies to liver cancer. “The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from the circulation into liver cells,” write the investigators. “Here, we sought to determine whether SLC13A5 regulates hepatic energy homeostasis and proliferation of hepatoma cells.  RNAi-mediated silencing of SLC13A5 expression in two human hepatoma cell lines, HepG2 and Huh7, profoundly ...

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