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[Comment] T cells and Parkinson's disease

20:06 EDT 11 Aug 2017 | The Lancet

Although effector and regulatory T-cell populations can promote either neurotoxic or neuroprotective effects in the control of the brain's microenvironment, how these cells are induced during Parkinson's disease is not known.1,2 David Sulzer and colleagues3 have reported a functional role of α-synuclein in immune tolerance. The authors posit that lymphocyte populations emerge from α-synuclein induction of autoreactive CD4+ and CD8+ T cells.

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