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ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

04:56 EDT 31 Aug 2017 | Nature Publishing

Skamagki et al. show that pluripotency factor ZSCAN10 is poorly expressed in iPSCs derived from aged donors, and its addition during reprogramming restores the DNA damage response and genomic stability through normalization of ROS–glutathione levels.

Original Article: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...