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Researchers at the University of Alabama (UAB) at Birmingham report the discovery of an important role for the RSF1, or remodeling and spacing factor 1, protein in silencing genes. They also demonstrated that disrupting RSF1 expression in the embryos of African clawed frogs caused severe developmental defects in the tadpoles. This took place via a dysregulation of mesodermal cell fate specification. The team published its paper ("Role of Remodeling and Spacing Factor 1 in Histone H2A Ubiquitination-Mediated Gene Silencing") in Proceedings of the National Academy of Sciences. Understanding how genes get turned on or off is critical for developing better therapies for diseases like cancer. “Histone H2AK119 ubiquitination (H2Aub), as mediated by Polycomb repressive complex 1 (PRC1), is a prevalent modification which has been linked to gene silencing. We report that remodeling and spacing factor 1 (RSF1), a subunit of the RSF complex, is a H2Aub-binding protein. ...
Original Article: Gene-Silencing Finding May Lead to Better Understanding of Some CancersNEXT ARTICLE
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...