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Drugs targeting the beta2-adrenoreceptor linked to Parkinson's disease

10:00 EDT 31 Aug 2017 | Medical Xpress

Lewy bodies - abnormal clumps of alpha-synuclein protein that accumulate in the brain - are a hallmark of Parkinson's disease (PD). Traditional drug development approaches for PD have focused on clearing alpha-synuclein from the brain or on preventing its downstream effects. But researchers from Brigham and Women's Hospital want to prevent alpha-synuclein from accumulating in the first place. To do so, the team searched for drugs that turn down alpha-synuclein production. They then tested the drugs in mice and stem cells and studied the health records of millions of people living in Norway.

Original Article: Drugs targeting the beta2-adrenoreceptor linked to Parkinson's disease

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