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Study Shows Universal Sequencing Detects More Cancer Mutations

07:04 EDT 5 Sep 2017 | Genetic Engineering News

Simultaneous sequencing of tumor DNA and normal tissue for a broad panel of cancer-related genes may detect more potentially clinically significant heritable mutations than a targeted approach based on current clinical guidelines, according to a study published by researchers at Memorial Sloan Kettering Cancer Center (MSK). The study by Kenneth Offit, M.D., chief of the Clinical Genetics Service and Robert and Kate Niehaus Chair in Inherited Cancer Genomics at MSK, found that more than half of inherited cancer gene mutations in people with advanced cancer were not detected using traditional methods based on family history. Those results suggest that current guidelines for genetic testing based on family history may not detect all clinically actionable genetic mutations, the MSK researchers concluded. But while knowledge of the additional mutations creates opportunities for precision prevention for patients’ families, and can help guide therapy as well as preventive interventions among ...

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