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Simultaneous sequencing of tumor DNA and normal tissue for a broad panel of cancer-related genes may detect more potentially clinically significant heritable mutations than a targeted approach based on current clinical guidelines, according to a study published by researchers at Memorial Sloan Kettering Cancer Center (MSK). The study by Kenneth Offit, M.D., chief of the Clinical Genetics Service and Robert and Kate Niehaus Chair in Inherited Cancer Genomics at MSK, found that more than half of inherited cancer gene mutations in people with advanced cancer were not detected using traditional methods based on family history. Those results suggest that current guidelines for genetic testing based on family history may not detect all clinically actionable genetic mutations, the MSK researchers concluded. But while knowledge of the additional mutations creates opportunities for precision prevention for patients’ families, and can help guide therapy as well as preventive interventions among ...
Original Article: Study Shows Universal Sequencing Detects More Cancer MutationsNEXT ARTICLE
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
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